Integrated Bus Timetabling and Scheduling with a Mutation-Based Evolutionary Scheme Maximizing Headway Quality and Connections

Public transport planning is a multi-level process that includes various complex tasks. These tasks are traditionally executed sequentially, and the result of each task serves as input for consecutive tasks. A simultaneous integrated consideration of multiple tasks may lead to an overall improved solution, but further increase the complexity of already hard-to-solve planning problems. This work focuses on timetabling and vehicle scheduling and evaluates synergies from the integrated optimization. We investigate an exact sequential, exact integrated, and heuristic approach to solve the combined problem for large public transport networks considering the interlining of vehicles, multiple vehicle types, or multiple depots while additionally aiming to maximize regular “clock-faced’’ headways and transfer connections. Compared to sequential optimization, an integrated approach significantly reduces nominal and operational costs while maintaining high service quality. However, an exact integrated approach is only able to compute solutions for problems of limited size in a reasonable time. We propose an adaptive modular evolutionary extendable scheme that effectively balances computational efficiency and solution quality. By utilizing various problem-specific mutation operators and adaptively applying them based on their impact, the heuristic can compute high-quality solutions for large real-world-inspired public transport networks in a reasonable time while considering short connecting times between lines and regular clock-faced headways

Ghent University-IBCN participation in TAC-KBP 2014 slot filling and cold start tasks

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Diluted planar ferromagnets: nonlinear excitations on a non-simply connected manifold

We study the behavior of magnetic vortices on a two-dimensional support manifold being not simply connected. It is done by considering the continuum approach of the XY-model on a plane with two disks removed from it. We argue that an effective attractive interaction between the two disks may exist due to the presence of a vortex. The results can be applied to diluted planar ferromagnets with easy-plane anisotropy, where the disks can be seen as nonmagnetic impurities. Simulations are also used to test the predictions of the continuum limit.Comment: 5 pages, 6 figure

VoiceCoach: Interactive evidence-based training for voice modulation skills in public speaking

The modulation of voice properties, such as pitch, volume, and speed, is crucial for delivering a successful public speech. However, it is challenging to master different voice modulation skills. Though many guidelines are available, they are often not practical enough to be applied in different public speaking situations, especially for novice speakers. We present VoiceCoach, an interactive evidence-based approach to facilitate the effective training of voice modulation skills. Specifically, we have analyzed the voice modulation skills from 2623 high-quality speeches (i.e., TED Talks) and use them as the benchmark dataset. Given a voice input, VoiceCoach automatically recommends good voice modulation examples from the dataset based on the similarity of both sentence structures and voice modulation skills. Immediate and quantitative visual feedback is provided to guide further improvement. The expert interviews and the user study provide support for the effectiveness and usability of VoiceCoach.Comment: Accepted by CHI '2

Characterizing, modelling and understanding the climate variability of the deep water formation in the North-Western Mediterranean Sea

Observing, modelling and understanding the climate-scale variability of the deep water formation (DWF) in the North-Western Mediterranean Sea remains today very challenging. In this study, we first characterize the interannual variability of this phenomenon by a thorough reanalysis of observations in order to establish reference time series. These quantitative indicators include 31 observed years for the yearly maximum mixed layer depth over the period 1980–2013 and a detailed multi-indicator description of the period 2007–2013. Then a 1980–2013 hindcast simulation is performed with a fully-coupled regional climate system model including the high-resolution representation of the regional atmosphere, ocean, land-surface and rivers. The simulation reproduces quantitatively well the mean behaviour and the large interannual variability of the DWF phenomenon. The model shows convection deeper than 1000 m in 2/3 of the modelled winters, a mean DWF rate equal to 0.35 Sv with maximum values of 1.7 (resp. 1.6) Sv in 2013 (resp. 2005). Using the model results, the winter-integrated buoyancy loss over the Gulf of Lions is identified as the primary driving factor of the DWF interannual variability and explains, alone, around 50 % of its variance. It is itself explained by the occurrence of few stormy days during winter. At daily scale, the Atlantic ridge weather regime is identified as favourable to strong buoyancy losses and therefore DWF, whereas the positive phase of the North Atlantic oscillation is unfavourable. The driving role of the vertical stratification in autumn, a measure of the water column inhibition to mixing, has also been analyzed. Combining both driving factors allows to explain more than 70 % of the interannual variance of the phenomenon and in particular the occurrence of the five strongest convective years of the model (1981, 1999, 2005, 2009, 2013). The model simulates qualitatively well the trends in the deep waters (warming, saltening, increase in the dense water volume, increase in the bottom water density) despite an underestimation of the salinity and density trends. These deep trends come from a heat and salt accumulation during the 1980s and the 1990s in the surface and intermediate layers of the Gulf of Lions before being transferred stepwise towards the deep layers when very convective years occur in 1999 and later. The salinity increase in the near Atlantic Ocean surface layers seems to be the external forcing that finally leads to these deep trends. In the future, our results may allow to better understand the behaviour of the DWF phenomenon in Mediterranean Sea simulations in hindcast, forecast, reanalysis or future climate change scenario modes. The robustness of the obtained results must be however confirmed in multi-model studies

Serum microRNA screening and functional studies reveal miR-483-5p as a potential driver of fibrosis in systemic sclerosis

Abstract Objective MicroRNAs (miRNAs) are regulatory molecules, which have been addressed as potential biomarkers and therapeutic targets in rheumatic diseases. Here, we investigated the miRNA signature in the serum of systemic sclerosis (SSc) patients and we further assessed their expression in early stages of the disease. Methods The levels of 758 miRNAs were evaluated in the serum of 26 SSc patients as compared to 9 healthy controls by using an Openarray platform. Three miRNAs were examined in an additional cohort of 107 SSc patients and 24 healthy donors by single qPCR. MiR-483-5p expression was further analysed in the serum of patients with localized scleroderma (LoS) (n = 22), systemic lupus erythematosus (SLE) (n = 33) and primary Sjogren's syndrome (pSS) (n = 23). The function of miR-483-5p was examined by transfecting miR-483-5p into primary human dermal fibroblasts and pulmonary endothelial cells. Results 30 miRNAs were significantly increased in patients with SSc. Of these, miR-483-5p showed reproducibly higher levels in an independent SSc cohort and was also elevated in patients with preclinical-SSc symptoms (early SSc). Notably, miR-483-5p was not differentially expressed in patients with SLE or pSS, whereas it was up-regulated in LoS, indicating that this miRNA could be involved in the development of skin fibrosis. Consistently, miR-483-5p overexpression in fibroblasts and endothelial cells modulated the expression of fibrosis-related genes. Conclusions Our findings showed that miR-483-5p is up-regulated in the serum of SSc patients, from the early stages of the disease onwards, and indicated its potential function as a fine regulator of fibrosis in SSc